Minocycline-induced chronic interstitial nephritis?

Acute interstitial nephritis is a rare complication of tetracycline therapy and there have been two case reports associated with minocycline [1,2]. In both cases the patients presented within 2 weeks of commencing the antibiotic with an acute febrile illness and loin pain, and an acute interstitial nephritis was confirmed on renal biopsy. We report a case of chronic interstitial nephritis in a patient who presented 6 months after commencing minocycline therapy whose renal function returned to normal after withdrawal of minocycline and a short course of steroids.